Regulation of Cellular signal transduction Laboratory

Ping Wang

Introduction to Prof. Ping Wang

Ping Wang graduated from Fudan University with a Bachelor degree in 1997 and received a Ph.D. Degree from Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences in 2002. He completed his postdoctoral training in University of Minnesota, University of Connecticut Health Center, and Yale University from 2003 to 2008. Upon completing his postdoctoral training, he was appointed Professor at College of Life Science, East China Normal University in 2008. Dr. Ping Wang has published 18 research articles in high impact journals with over 400 citations. After return to China, he has got the grants from National Natural Science Foundation, the Ministry of Science and Technology of China, Shanghai Educational Department, and Science and Technology Commission of Shanghai Municipality.

Research Interests:Regulation of Cellular signal transduction

1.Signal transduction of inflammation. We are interested in studying the underlying mechanisms by which regulate the function of neutrophil, macrophage, and endothelial cells during the inflammation.

2.Cancer signal transduction. We are focusing on the study of the mechanisms by which regulates the function of those proteins with essential roles in tumorigenesis and metastasis by posttranslational modification, including ubiquitination, phosphorylation and acetylation.

3.Stem cell signal transduction. We are interested in understanding the role of protein degradation system in the regulation of stem cell functions.

Publications:

1. Xiao N, Li H, Luo J, Wang R, Chen H, Chen J, Wang P. Ubiquitin-Specific Protease 4 (USP4) targets TRAF 2 and TRAF6 for deubiquitination and inhibits TNFa-induced cancer cell migration. Biochem J. 2012 441,979-986

2. Wang Q, Xu X, Li J, Liu J, Gu H, Zhang R, Chen J, Kuang Y, Fei J, Jiang C, Wang P, Pei D, Ding S, Xie X. Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells. Cell Res. 2011 Jul 5. doi: 10.1038/cr.2011.108.

3. Wenwen Xu *, Ping Wang *#, Björn Petri, Yong Zhang, Wenwen Tang, Le Sun, Holger Kress, Tom Mann, Yan Shi, Paul Kubes & Dianqing Wu#. Important Roles of PIP5K1C in Neutrophil Recruitment Immunity 2010 33(3): 340-50 (Co-corresponding author)

4. Li C, Yang Z, Li Z, Ma Y, Zhang L, Zheng C, Qiu W, Wu X, Wang X, Li H, Tang J, Qian M, Li D, Wang P, Luo J, Liu M. Maslinic acid suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating RANKL-mediated NF-kappaB and MAPK signaling pathways. J Bone Miner Res. 2010 Sep 2.

Liu N, Li H, Li S, Shen M, Xiao N, Chen Y, Wang Y, Wang W, Wang R, Wang Q, Sun J, Wang P. The Fbw7/hCDC4 tumor suppressor targets pro-proliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs. J Biol Chem. 2010 285(24):18858-67. (Corresponding author)

6. Wang Z, Kumamoto Y, Wang P, Gan X, Lehmann D, Smrcka AV, Cohn L, Iwasaki A, Li L, Wu D. Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5. J Biol Chem. 2009 Oct 16; 284(42):28599-606.

7. Wang Z, Liu B, Wang P, Dong X, Fernandez-Hernando C, Li Z, Hla T, Li Z, Claffey K, Smith JD, Wu D. Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice. J Clin Invest. 2008 Jan 2;118(1):195-204

8. Ping Wang, Jing Nie and Duanqing Pei. The hemopexin domain of MT1-MMP is not required for its activation of proMMP2 on cell surface, but essential for MT1-MMP mediated invasion in 3-D type I collagen. J Biol Chem. 2004 Dec 3;279(49):51148-51155，

9. Ping Wang, Xing Wang and Duanqing Pei. Mint-3 regulates the retrieval of internalized MT5-MMP to plasma membrane by binding to its carboxyl end motif EWV. J Biol Chem. 2004 May 7;279 (19):20461-20470.

10. Ping Wang, Tortorella M, England K, Malfait AM, Thomas G, Arner L, Pei D. Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (aggrecanase-1) in the trans-Golgi network. J Biol Chem. 2004, April 9, 279(15):15434-15440.

11. Ping Wang*, Hua Gao*, Yanxiang Ni, Beibei Wang, Yalan Wu, Linhua Qin, Lan Ma, Gang Pei. -arrestin 2 functions as a GPCR-activated regulator of oncoprotein Mdm2. J Biol Chem. 2003 Feb 21; 278(8):6363-6370.

12. Ping Wang, Ya-Lan Wu, Xin Ge, and Gang Pei. Subcellular localization of beta-arrestins is determined by their intact N domain and the nuclear export signal at the C terminus. J Biol Chem. 2003 Mar 28;278(13):11648-11653.

13. Ping Wang *, Ya-Lan Wu*, Tian-Hua Zhou, Yue Sun and Gang Pei (2000), Identification of alternative splicing variants of the  subunit of human Ca2+/calmodulin-dependent protein kinase II with different activities. FEBS Letters 475 (2000) 107-110.

14. Kun Ling*, Ping Wang*, Jian Zhao*, Ya-Lan Wu, Zhijie Cheng, Guo-Xiang Wu, Wei Hu, Lan Ma and Gang Pei. (1999) Five-transmembrane domains appear sufficient for a G protein-coupled receptor: Functional five-transmembrane domain chemokine receptors. Proc. Natl. Acad. Sci. USA. 1999 July. 96: 7922-7927.

15. Jian Qiu, Ping Wang, Qing Jing, Wenbo Zhang, Xiaoyu Li, Yongping Zhong, Gang Sun, Gang Pei and Yizhang Chen. (2001) Rapid Activation of ERK1/2 Mitogen-Activated Protein Kinase by Corticosterone in PC12 Cells. Biochemical and Biophysical Research Communications 287, 1017–1024.

16. Liguang Lou, Tianhua Zhou, Ping Wang, and Gang Pei. (1999). Modulation of Ca2+ /Calmodulin-Dependent Protein Kinase II Activity by Acute and Chronic Morphine Administration in Rat Hippocampus: Differential Regulation of alpha and beta Isoforms. Molecular Pharmacology, 1999, 55:557–563.

17. Qing Jing, Sun-Mei Xin, Wen-Bo Zhang, Ping Wang, Yong-Wen Qin, Gang Pei.( 2000). Lysophosphatidylcholine Activates p38 and p42/44 Mitogen-Activated Protein Kinases in Monocytic THP-1 Cells, but Only p38 Activation Is Involved in Its Stimulated Chemotaxis. Circ Res. 2000;87:52-59.)

18. Jian Zhao, Lan Ma, Ya-lan Wu, Ping Wang, Wei Hu and Gang Pei (1998). Chemokine Receptor CCR5 functionally couples to inhibitory G protein and undergoes desensitization. Journal of Cellular Biochemistry 1998, 71:36-45.