Title : Systematic analysis of Th17 network reveals novel IL-23 signaling circuits

Speaker: Chuan Wu, Postdoctoral fellow in Dr. Vijay Kuchroo’s lab, Dep. Neurology, Brigham and Women’s Hospital, Harvard Medical School, USA

Host: Prof. Yuping Lai

When: 2012-11-28  13:30

Where: Conference Room 534, School of Life Sciences

Abstract：We used unbiased transcriptional profiling of developing Th17 cells to construct a model of their signaling network and identify major nodes that regulate Th17 development. We identified serum glucocorticoid kinase-1 (SGK1), as an essential node downstream of IL-23 signaling, critical for regulating IL-23R expression and for stabilizing Th17 cell phenotype.