Title : Thymic stromal lymphopoietin enhances Th2/Th22 and reduces IL-17A in protease allergen induced airways lung inflammation

Speaker: Bernhard Ryffel

Host: Prof. Yuping Lai

When: 2012-12-5  13:30

Where: Conference Room 534, School of Life Sciences

Abstract：Here we report that mice challenged with house dust mite extract or papain in the absence of TLSPR have a drastic reduction of allergic inflammation with diminished eosinophil recruitment in BAL and lung and reduced mucus overproduction. TLSPR deficient DCs displayed diminished antigen uptake and reduced capacity to activate antigen specific T cells. TLSPR deficient mice had diminished proinflammatory IL-1, IL-13 and IL-33 and chemokines production. Together with impaired Th2 cytokines, IL-17A expressing TCRab+ T cells were increased, while IL-22 expressing T cells were diminished in the lung.