Dec 2: Acetylation Control of Metabolic Enzymes in Cancer
Speaker：Qunying Lei
Host: Ping Wang
When: 2013-12-2 13:30
Where: Conference Room 534, School of Life Sciences
Abstract: Metabolic reprogramming is one of the critical features in cancer. Tumor cells preferentially utilize glycolysis instead of oxidative phosphorylation in the presence of oxygen, namely "Warburg Effect". Recent studies have provided new insights into the Warburg effect, elucidating metabolic-dependent and independent mechanisms of metabolic enzymes regulated by posttranslational modifications and providing further evidences of the critical role of these tricks in cancer metabolism and tumorigenesis. Of particular interest, I will use three metabolic enzymes we studied as an example to elucidate how acetylation control of cancer metabolism via the metabolic and non-metabolism manner.