Innate Immunity and Immunoregulation

Min Qian, Ph.D

Professor of Immunology

Vice Dean of School of life Sciences

Shanghai Key Laboratory of Regulatory Biology

School of Life Sciences

East China Normal University

Tel: 86-21-54341039

Fax: 86-21-54344922

Email: mqian@bio.ecnu.edu.cn

Dr. Qian received her Ph.D. degree in 1991 from the Department of Biology, East China Normal University. After that, she worked as a research assistant in East China Normal University from 1991. Then she was promoted to Associate Professor in 1994 and Professor in 2002. In the past 10 years, she has been awarded lots of honors such as Excellent Young Scientist of Shanghai, Woman Pacesetter of Shanghai and Excellent Supervisor Award of Shanghai from Shanghai Municipal Government.

Now her research interests are focused on understanding the regulation of innate immune responses by GPCRs in inflammation, cancer and infectious disease. She has published more than 120 papers on high impact journals including J Immunol, Int J Cancer and Mol Cancer Res. Her current research is supported by grants from the National Natural Science Foundation of China, the Ministry of Science and Technology of China and the Science and Technology Commission of Shanghai Municipality.

Members of Qian’s Group

Principal Members

Wenzheng Jiang, Professor                          Bing Du, Associate Professor                          Hua Ren, Instructor

Research interests

Our research interests are focused on inflammation, infectious disease and cancer, including:

1. To understand the role and mechanism of GPCRs in regulation of TLR, NLR and RLR mediated innate immune response in Macrophage, NK cells and Dendritic cell.
2. To understand the function of inflammation in occurrence and progression of tumor, neurodegenerative disease and autoimmune diseases in mouse models.
3. To understand the function and mechanism of extracellular nucleotides and their receptors in regulation of host defense against bacterial and viral infection.

Publications (last 3 years):

1. Tang Zhewei, Mingqian Feng, Wei Gao, Yen Phung, Weizao Chen, Amit Chaudhary, Brad St. Croix, Min Qian, Dimiter S. Dimitrov, Mitchell Ho*. A human single-domain antibody elicits potent anti-tumor activity by targeting an epitope in mesothelin close to the cancer cell surface. Mol Cancer Therapeutics，2013 Jan 31. [Epub ahead of print]
2. Tang Zhewei，Min Qian，Mitchell Ho*．The Role of Mesothelin in Tumor Progression and Targeted Therapy．Anti-cancer Agents in Medicinal Chemistry．13：276-280，2013
3. Zhao, Q., Y. Qian, R. Li, B. Tan, H. Han, M. Liu, M. Qian, and B. Du*. 2012. Norcantharidin Facilitates LPS-Mediated Immune Responses by Up-Regulation of AKT/NF-kappaB Signaling in Macrophages. PLoS ONE 7: e44956.
4. Wang, Z., W. Jiang, Z. Zhang, M. Qian, and B. Du*. 2012. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kappaB pathway in RAW 264.7 cells. J Ethnopharmacol 144: 145-150.
5. Jiang W*. Blockade of B7-H1 enhances dendritic cell-mediated T cell response and antiviral immunity in HBV transgenic mice. Vaccine 2012, 30(4): 758-766.
6. Du J, Long F, Wen J, Hao W, Qian M, Jiang W*. Improvement in efficacy of DNA vaccine encoding HIV-1 Vif by LIGHT gene adjuvant. Viral Immunol. 2012
7. Wenzheng Jiang，Noo Ri Chai，Dragan Maric，Bibiana Bielekova．Unexpected Role for Granzyme K in CD56bright NK Cell-Mediated Immunoregulation of Multiple Sclerosis．The Journal of Immunology．2011，187(2)：781-790
8. Xinhua Pan，Honghui Han，Lei Wang，Linli Yang，Ruimei Li，Zhenxi Li，Junchen Liu，Qufei Zhao，Min Qian，Mingyao Liu*，Bing Du*．Nitidine Chloride inhibits breast cancer cells migration and invasion by suppressing c-Src/FAK associated signaling pathway．Cancer Letters．2011，313(2)：181-91
9. Zhi Zhang，Ziqiang Wang，Hua Ren，Miaomiao Yue，Kan Huang，Hongjie Gu，Mingyao Liu，Bing Du* and Min Qian*．P2Y6 agonist UDP promotes host defense against bacterial infection via MCP-1 mediated monocytes/macrophages recruitment．The Journal of Immunology，2011，186（9）: 5376-5387
10. Lisha Kuang，Lei Wang，Qian Wang，Qufei Zhao，Bing Du，Dali Li，Jian Luo，Mingyao Liu，Aijun Hou* and Min Qian*．Cudratricusxanthone G inhibits human colorectal carcinoma cell invasion by MMP-2 down-regulation through suppressing activator protein-1 activity．Biochemical Pharmacology，2011，81(10)：1192-200
11. Li C, Yang Z, Zhai C, Qiu W, Li D, Yi Z, Wang L, Tang J, Qian M, Luo J* and Liu M*. Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor α by inhibiting NF-κB signaling pathway. Mol Cancer, 2010, 9:73
12. Han H, Du B, Pan X, Liu J, Zhao Q, Lian X, Qian M* and Liu M*. CADPE inhibits PMA-stimulated gastric carcinoma cell invasion and matrix metalloproteinase-9 expression by FAK/MEK/ERK-mediated AP-1 activation. Mol  Cancer Res, 2010, 8(11):1477-1488
13. Yu L, Feng M, Kim H, Phung Y, Kleiner DE, Gores GJ, Qian M, Wang XW and Ho M*. Mesothelin as a potential therapeutic target in human cholangiocarcinoma. Journal of Cancer,  2010, 1:141-149.
14. Wang L, Kuang L, Pan X, Liu J, Wang Q, Du B, Li D, Luo J, Liu M, Hou A* and Qian M*. Isoalvaxanthone inhibits colon cancer cell proliferation, migration and invasion through inactivating Rac1 and AP-1. International Journal of Cancer, 2010, 127(5):1220-1229
15. Meng J, Yue M, Han H, Zhou z, Qian M, Du B*. Targeted Therapy for Hepatocarcinoma-specific Peptide A54  in vitro. Current Immunology, 2010, 30(3):217-221
16. Du B, Han H, Wang Z, Kuang L, Wang L, Yu L, Wu M, Zhou Z* and Qian M*. Targeted drug delivery to hepatocarcinoma in vivo by phage-displayed specifically binding peptide. Molecular Cancer Research, 2010, 8(2):135-144

Books:

1.  Zhang G, Chen T, Qian M. 2008,  Help you identify what the immune. Science Press. Beijing

2.  Qian M, Ma Duan. 2008, Immunobiology (translations). ed Charles A. Janeway, Immunology(5th） Science Press. Beijing

3.  Qian M and Du Bing. 2007, Chapter 9: Construction and Application of peptides Library. Biology front technology in the applications in medical research，ed. Ma Duan. Fudan University Press, Shanghai

4.  Qian M. Immunology Principle and Technology, 2011, Higher Education Press, Beijing