Laboratory of Epigenetics
 | Jiemin Wong |
| Vice Dean,The Institute of Biomedical Sciences | |
| Vice Director, Institute of Biomedical Sciences and Shanghai Key Laboratory of Regulatory Biology |
Personal Introduction
Dr. Jiemin Wong obtained his BS degree from Wuhan University in 1984 and his Ph.D. degree from the Department of Microbiology and Molecular Genetics, University of Vermont in 1994. He then did a three year postdoc training at the National Institute of Child Health and Development in NIH. In 1997, Dr. Wong moved to Baylor College of Medicine as an Assistant Professor at the Department of Molecular and Cellular Biology and he was promoted to Associate Professor in 2003. In 2007 he joined the School of Life Sciences, East China Normal University as a professor and the Associate Director of the Institute of Biomedical Sciences. Dr. Wong’s laboratory has been interested in epigenetic regulation and transcriptional regulation by nuclear hormone receptors (NRs). His group has made significant contribution to the identification and characterization of the corepressor complexes of nuclear hormone receptors. He received the Richard E. Weitzman Memorial Award from Endocrine Society in 2001. He has published more than 80 papers on top journals including Cell, Nature and Science. His current research is supported by grants from the National Natural Science Foundation of China, the Ministry of Science and Technology of China and the Science and Technology Commission of Shanghai Municipality.
Research Interests
1.The Mechanisms of Epigenetic Regulation
(1) Histone Methylation and Demethylation
(2) Deciphering histone modification codes
(3) DNA de novo and maintenance methylation and the cross-talk between histone modification and DNA methylation
2.Transcriptional Regulation By Nuclear Hormone Receptors
(1) Transcription Regulation by Androgen Receptor
(2) Mechanism and Biological Function of the Coregulators of Nuclear Hormone Receptor
3.ES cell epigenetic regulation
Publications in 2012
1. Li, J., Chu, M., Wang, S., Chan, D., Qi, S., Wu, M., Zhou, Z., Li, J., Nishi, E., Qin, J. Wong J. 2012. Identification and Characteriation of Nardilysin as a Novel Dimethyl H3K4 Binding Protein Involved in Transcriptional Regulation. J Biol Chem. 287(13):10089-98
2. Wu J, Cui N, Wang R, Li J and Wong J. 2012. A role for CARM1-mediated histone H3 methylation in protecting histone acetylation by releasing corepressors from chromatin. PLoS One 7(6):e34692
3. Zhang H, Ma Y, Gu J, Liao B, Li J, Wong J*, Jin Y*. 2012. Reprogramming of somatic cells via TAT-mediated protein transduction of recombinant factors. Biomaterials 33:5047-5055. * Co-corresponding author
4. Hu C, Zhang S, Gao X, Gao X, Xu X, Lv Y, Zhang Y, Zhu Z, Zhang C, Li Q, Wong J, Cui Y, Zhang W, Ma L, Wang C. 2012.Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response. J Biol Chem 287(23):18937-53.
5. Cong R, Das S, Ugrinova I, Kumar S, Mongelard F, Wong J, Bouvet P. 2012. Interaction of nucleolin with ribosomal RNA genes and its role in RNA polymerase I transcription. Nucleic Acids Research 40(19):9441-54
6. Li J, Zhou F, Zhan D, Gao Q, Cui N, Li J, Iakhiaeva E, Zwieb C, Lin B, Wong J. 2012. A novel Histone H4 Arginine 3 methylation-sensitive histone H4 binding activity and transcriptional regulatory function for signal recognition particle subunits SRP68 and SRP72. J Biol Chem [2012 Oct 8, Epub ahead of print]
7. Wu M, Wang L, Li Q, Li J, Qin J, Wong J. 2012. The MTA family proteins as novel histone H3 binding proteins. Cell & Biosciences. In press
8. Zhang Q, Qi S, Xu M, Yu L, Tao Y, Wu W, Chen Z* and Wong J* 2012. Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b . In press (Cell Research) * Co-corresponding author
9. Liu x, Gao Q, Li P, Zhang J, Li J, Koseki H, Wong J. UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9. In revision (Nature Communication