报告题目：Histone onco-mutations and cancer epigenomes
报告人：Dr. Zhiguo Zhang, Professor of Pediatrics and Professor of Genetics and Development, Institute for Cancer Genetics, Columbia University.
主持人：翁杰敏 教授
报告时间：2017年11月2日 13:30-15:00
报告地点：闵行生命科学学院534报告厅
主办单位：生命科学学院，科技处
报告人简介： Dr. Zhiguo Zhang is a professor of Department of Biochemistry and Molecular Biology. He has a broad background in biochemistry, genetics, epigenetics and cancer epigenetics. He devoted himself to elucidate how epigenetically determined chromatin states are inherited during S phase of the cell cycle and to understand how epigenetic alterations promote tumorigenesis and drug resistance in gliomas. Since the establishment of his laboratory in 2003, they have made significant contributions to understanding how nucleosome assembly pathways are regulated in yeast and human cells, and how onco-histone mutations found in pediatric glioma and chondroblastoma reprogram cancer epigenome and drive tumorigenesis. He has published many papers about their discoveries in PNAS, Science, Nature, Cell, Molecular Cell and Genes and Development.
教育经历：
1988.07 B.S. National University of Defense Technology
1992.10 Ph.D candidate Dalian Institute of Chemical Physics, China
1998.10 Ph.D. University of Utah, Salt Lake City, UT
1998.10-2003.04 Postdoctoral Cold Spring Harbor Lab, Cold Spring Harbor, NY
工作经历：
1988-1989 Research Technician, Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian, China
2003-2008 Assistant Professor, Department of Biochemistry and Molecular Biology, Mayo Clinic Rochester, Rochester, MN
2008-2012 Associate Professor, Department of Biochemistry and Molecular Biology, Mayo Clinic Rochester, Rochester, MN
2012-2016 Professor, Department of Biochemistry and Molecular Biology, Mayo Clinic Rochester, Rochester, MN
2016-present Professor of Pediatrics and Professor of Genetics and Development, Institute for Cancer Genetics, Columbia University