A) 第一作者单位发表论文
1. Yang J, Zhang Q, Chang H, Cheng Y*. Surface-engineered Dendrimers in Gene Delivery, Chemical Reviews, 2015, 115(11), 5274-5300.
2. Deng L, Jiang C, Chen L, Jin J, Wei J, Zhao L, Chen M, Pan W, Xu Y, Chu H, Wang X, Ge X, Li D, Liao L, Liu M, Li L, Wang P*. The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation. Mol Cell. 2015 Jun 4; 58(5):804-18.
3. Li L*, Dang Y, Zhang J, Yan W, Zhai W, Chen H, Li K, Tong L, Gao X, Amjad A, Ji L, Jing T, Jiang Z, Shi K, Yao L, Song D, Liu T, Yang X, Yang C, Cai X, Xu W, Huang Q, He J, Liu J, Chen T, Moses RE, Fu J, Xiao J, Li X. REGγ is critical for skin carcinogenesis by modulating the Wnt/β-catenin pathway. Nat Commun. 2015 Apr 24; 6: 6875.
4. Fan G, Sun L, Shan P, Zhang X, Huan J, Zhang X, Li D, Wang T, Wei T, Zhang X, Gu X, Yao L, Xuan Y, Hou Z, Cui Y, Cao L, Li X, Zhang S*, Wang C*. Loss of KLF14 triggers centrosome amplification and tumorigenesis. Nat Commun. 2015 Oct 6; 6: 8450.
5. Wang H, Wang Y, Wang Y, Li T, Liu H, Zhang Q, Cheng Y*. Self-assembled Fluorodendrimers Combine the Features of Lipid and Polymeric Vectors in Gene Delivery. Angew. Chem. Int. Ed., 2015, 54, 11647-11651.
6. Tang B, Wang T, Wan H, Han L, Qin X, Zhang Y, Wang J, Yu C, Berton F, Francesconi W, Yates JR 3rd, Vanderklish PW, Liao L*. Fmr1 deficiency promotes age-dependent alterations in the cortical synaptic proteome. Proc Natl Acad Sci U S A. 2015 Aug 25; 112 (34):E4697-706.
7. Li P, Liu Y, Wang H, He Y, Wang X, He Y, Lv F, Chen H, Pang X, Liu M, Shi T*, Yi Z*. PubAngioGen: a database and knowledge for angiogenesis and related diseases. Nucleic Acids Research 2015, 43 (D1): D963-D967.
8. Wang W, Liao P, Shen M, Chen T, Chen Y, Li Y, Lin X, Ge X and Wang P*. SCP1 regulates c-Myc stability and functions through dephosphorylating c-Myc Ser62, Oncogene, 2015.
9. Wang C, Cai X, Zhang J, Wang X, Wang Y, Ge H, Yan H, Huang Q, Xiao J*, Zhang Q*, Cheng Y*. Trifolium-like Platinum Nanoparticle-Mediated Photothermal Therapy Inhibits Tumor Growth and Osteolysis in a Bone Metastasis Model. Small, 2015, 11, 2080-2086.
10. Li S, Jiang C, Pan J, Wang X, Jin J, Zhao L, Pan W, Liao G, Cai X, Li X, Xiao J, and Wang P. Regulation of c-Myc protein stability by proteasome activator REGγ. Cell Death and Differentiation. 2015 Jun; 22(6):1000-11.
11. Lv Y, Meng B, Dong H, Jing T, Wu N, Yang Y, Huang L, Moses RE, O'Malley BW, Mei B, Li X. Upregulation of GSK3β Contributes to Brain Disorders in Elderly REGγ-knockout Mice. Neuropsychopharmacology. 2015 Sep 15.
12. Shao N, Dai T, Liu Y, Cheng Y*. A Supramolecular Approach to Improve the Gene Transfection Efficacy of Dendrimers, Chemical Communications, 2015, 51, 9741-9743.
13. Wang X, Wang C, Zhang Q*, Cheng Y*. Near-infrared Light-Responsive and Injectable Supramolecular Hydrogels for On-demand Drug Delivery, Chemical Communications, 2015, doi: 10.1039/C5CC08391E, in press.
14. Hu M, Peng S, He Y, Qin M, Cong X, Xing Y, Liu M, Yi Z*. Lycorine is a novel inhibitor of the growth and metastasis of hormone-refractory prostate cancer. Oncotarget. 2015 Jun 20; 6(17): 15348- 61.
15. Cai X, Luo J, Yang X, Deng H, Zhang J, Li S, Wei H, Yang C, Xu L, Jin R, Li Z, Zhou W, Ding J, Chu J, Jia L, Jia Q, Tan C, Liu M, Xiao J. In vivo selection for spine-derived highly metastatic lung cancer cells is associated with increased migration, inflammation and decreased adhesion. Oncotarget. 2015 Sep 8; 6(26):22905-17.
16. He B, Wang Y, Shao N, Chang H, Cheng Y*. Polymers Modified with Double-tailed Fluorous Compounds for Efficient DNA and siRNA Delivery, Acta Biomaterialia, 2015, 22, 111-119.
17. Wang F, Hu K, Cheng Y*. Structure-activity Relationship of Dendrimers Engineered with Twenty Common Amino Acids in Gene Delivery. Acta Biomaterialia, 2015, doi: 10.1016/j.actbio.2015.10.034, in press.
18. Chen G, Yu D, Chen J, Cao R, Yang J, Wang H, Ji X, Ning B, Shi T*. Re-annotation of presumed noncoding disease/trait-associated genetic variants by integrative analyses. Sci. Rep. 2015, 5:9453.
19. Lv Q, Ma W, Liu H, Li J, Wang H, Lu F, Zhao C, Shi T*. Genome-wide protein-protein interactions and protein function exploration in cyanobacteria. Sci. Rep. 2015, 5: 15519.
20. Wang L, Shao Y, Guan Y, Li L, Wu L, Chen F, Liu M, Chen H, Ma Y, Ma X, Liu M*, Li D*. Large genomic fragment deletion and functional gene cassette knock-in via Cas9 protein mediated genome editing in rodents one-cell embryos. Sci. Rep .2015, Dec; 5:17517.
21. Li J, Zeng L, Xie J , Yue Z, Deng H, Ma X, Zheng C, Wu X, Luo J*, Liu M. Inhibition of Osteoclastogenesis and Bone Resorption in vitro and in vivo by a prenylflavonoid Xanthohumol from hops. Sci Rep. 2015 Dec; 5:17605.
22. Lu W, Cheng F, Jiang J, Zhang C, Deng X, Xu Z, Zou S, Shen X, Tang Y, Huang J. FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach. Sci Rep. 2015; 5:8114.
23. Zhang Y, Liu S, Zuo Q, Wu L, Ji L, Zhai W, Xiao J, Chen J, Li X. Oxidative challenge enhances REGγ-proteasome-dependent protein degradation. Free Radic Biol Med. 2015 May; 82: 42-9.
24. Guan Y, Zhang L, Li X, Zhang X, Liu S, Gao N, Li L, Gao G, Wei G, Chen Z, Zheng Y, Ma X, Siwko S, Chen J*, Liu M, Li D*. Repression of Mammalian Target of Rapamycin Complex 1 Inhibits Intestinal Regeneration in Acute Inflammatory Bowel Disease Models. J Immunol. 2015 Jul 1; 195(1):339-46.
25. Li J, Zhang T, Yang F, He Y, Dai F, Gao D, Chen Y, Liu M*, Yi Z*. Inhibition of breast cancer progression by a novel histone deacetylase inhibitor, LW479, through down-regulating EGFR expression. Br J Pharmacol. 2015 Aug; 172(15):3817-30.
26. Lv J, Chang H, Wang Y, Wang M, Xiao J, Zhang Q, Cheng Y*. Fluorination on Polyethylenimine Allows Efficient 2D and 3D Cell Culture Gene Delivery, J. Mater. Chem. B. 2015, 3, 642-650.
27. Chang H, Zhang Y, Li L, Cheng Y*. Efficient Delivery of Small Interfering RNA into Cancer Cells Using Dodecylated Dendrimers, J. Mater. Chem. B. 2015, 3, 8197-8292.
28. Ji L, Xu J, Liu J, Amjad A, Zhang K, Liu Q, Zhou L, Xiao J, Li X. Mutant p53 promotes tumor cell malignancy by both positive and negative regulation of the transforming growth factor β (TGF-β) pathway. J Biol Chem. 2015 May 1; 290(18):11729-40.
29. Qi S, Wang Z, Li P, Wu Q, Shi T, Li J and Wong J*. Non-germline Restoration of Genomic Imprinting for a Subset of Imprinted Genes in Ubiquitin-like PHD and RING Finger Domain-Containing 1 (Uhrf1) Null Mouse Embryonic Stem Cells. J. Biol. Chem. 2015. 290(22):14181-91.
30. Yang J, Hu J, He B, Cheng Y*. Transdermal Delivery of Therapeutic Agents using Dendrimers (US20140018435A1): A Patent Evaluation, Expert Opinion on Therapeutic Patents. 2015, 25, 1209-1214.
31. Zhang Q*, Dong K, Wang C, Cheng Y*. Dramatic Shape Transformation of Ag Nanoparticles with Concave Profiles in a Solvothermal Process, CrystEngComm. 2015, 17, 7469-7472.
32. Dai F*, Chen Y*, Huang L, Wang J, Zhang T, Li J, Tong W, Liu M, Yi Z, A novel synthetic small molecule YH-306 suppresses colorectal tumor growth and metastasis via FAK pathway. J. Cell. Mol. Med. 2015, 19, 383-395.
33. Wang B, Yu W, Guo J, Jiang X, Lu W, Liu M*, Pang X*. The antiparasitic drug, potassium antimony tartrate, inhibits tumor angiogenesis and tumor growth in non-small cell lung cancer. J Pharmacol Exp Ther. 2015; 352(1):129-3828.
34. Qin M, Peng S, Liu N, Hu M, He Y, Li G, Chen H, He Y, Chen A, Wang X, Liu M, Chen Y*, Yi Z*. LG308, a novel synthetic compound with anti-microtubule activity in prostate cancer cells, exerts effective antitumor activity. J Pharmacol Exp Ther. 2015 Dec; 355(3):473-483.
35. Shao N, Wang H, He B, Wang Y, Xiao J, Wang Y, Zhang Q, Lia Y and Cheng Y *. Hydrogen -bonding dramatically modulates the gene transfection efficacy of surface-engineered dendrimers. Biomater. Sci., 2015, 3, 500.
36. Li Z, Su H, Yu W, Li X, Cheng H, Liu M, Pang X*, Zou X*. Design, synthesis and anticancer activities of novel otobain derivatives. Org Biomol Chem. 2015, DOI: 10.1039/C5OB02176F.
37. Zhou W, Huang A, Zhang Y, Lin Q, Guo W, You Z, Yi Z, Liu M*, Chen Y*. Design and optimization of hybrid of 2, 4-diaminopyrimidine and arylthiazole scaffold as anticancer cell proliferation and migration agents. Eur J Med Chem. 2015 Apr 13; 96:269-280.
38. Cui H, He Y, Wang J, Gao W, Liu T, Qin M, Wang X, Gao C, Wang Y, Liu M, Yi Z*, Qiu W*. Synthesis of heterocycle-modified betulinic acid derivatives as antitumor agents. Eur J Med Chem. 2015 May 5; 95: 240-8.
39. Chao R, Gong X, Wang L, Wang P and Wang Y*. (2015) CD71 high population represents primitive erythroblasts derived from mouse embryonic stem cells, Stem Cell Res. 14: 30-38.
40. Shi J, Li X, Zhang X, Du B, Jiang W, Liu M, Wang J, Wang Z, Ren H*, Qian M*. Gpr97 is dispensable for inflammation in OVA-induced asthmatic mice. PLoS One. 2015 10(7): e0131461.
41. Zheng C, Zhou W, Wang T, You P, Zhao Y, Yang Y, Wang X, Luo J, Chen Y, Liu M, Chen H. A Novel TGR5 Activator WB403 Promotes GLP-1 Secretion and Preserves Pancreatic beta-Cells in Type 2 Diabetic Mice. PLoS ONE. 2015, 10, e0134051.
42. Sun M, Tang Y, Ding T, Liu M, Wang X*. Investigation of cytochrome P450 inhibitory properties of maslinic acid, a bioactive compound from Olea europaea L., and its structure-activity relationship. Phytomedicine. 2015, 22, 56-65.
43. Chen A, Qin X, Lu J, Yi Z, Liu M, Wang X*. Development of a validated LC-MS/MS method for the determination of ailanthone in rat plasma with application topharmacokinetic study. J Pharm Biomed Anal. 2015 Jan; 102:514-518.
44. Zhang M, Jiang Z, Li D, Jiang D, Wu Y, Ren H, Peng H, Lai Y*. Oral antibiotic treatment induces skin microbiota dysbiosis and influences wound healing. Microb Ecol. 2015, 69(2):415-21.
45. Lai Y, Dong C. Therapeutic antibodies that target inflammatory cytokines in autoimmune diseases. Int Immunol. 2015, pii: dxv063. [Epub ahead of print] Review.
46. Wu D, Mei H, Tan P, Lu W, Zhu J, Wang W, Huang J, Li J. Total synthesis of the 2-arylbenzo [b] furan-containing natural products from Artocarpus. Tetrahedron Letters. 2015, 56(29):4383–4387.
47. Ding T, Zhang Y, Chen A, Tang Y, Liu M, Wang X*. Effects of Cucurbitacin E, a Tetracyclic Triterpene Compound from Cucurbitaceae, on the Pharmacokinetics and Pharmacodynamics of Warfarin in Rats. Basic & Clinical Pharmacology & Toxicology. 2015, 116, 385-389.
48. Lv J, Wang J, Chang S, Liu M*, Pang X*. The greedy nature of mutant RAS: a boon for drug discovery targeting cancer metabolism? Acta Biochim Biophys Sin. 2015, 1-10.
49. Li J, Zhang G, Cheng D, Ren H, Qian M, Du B*. Molecular characterization of RIG-I, STAT-1 and IFN-beta in the horseshoe bat. Gene. 561(1):115-23.
50. Lu J, Ding T, Qin X, Liu M, Wang X*. In vitro and in vivo evaluation of cucurbitacin E on rat hepatic CYP2C11 expression and activity using LC-MS/MS. Sci China Life Sci. 2015 Sep 9.doi: 10.1007/s11427-015-4911-7. [Epub ahead of print]
51. Shao N, Wang H, He B, Wang Y, Xiao J, Wang Y, Zhang Q, Li Y, Cheng Y*. Hydrogen- bonding Dramatically Modulates the Gene Transfection Efficacy of Surface-engineered Dendrimers, Biomaterials Sciences. 2015, 3, 500-508.
52. Wang M, Wang Y, Hu K, Shao N, Cheng Y*. Tumor Extracellular Acidity Activated “Off–on” Release of Bortezomib from a Biocompatible Dendrimer. Biomaterials Sciences, 2015, 3, 480-489.
53. 胡雪菲,江文正*. 人颗粒酶A活性段的表达、纯化及其活性鉴定.中国免疫学杂志. 2015 31(1): 77-81.
54. 郝文丽,赵勇,任华,江文正*. 人LIGHT-Fc融合蛋白在毕赤酵母中的表达及鉴定.中国生物制品学杂志. 2015 28(8): 20-23.
B) 合作发表论文
1. Yu Z, Zhou X, Wang W, Deng W, Fang J, Hu H, Wang Z, Li S, Cui L, Shen J, Zhai L, Peng S, Wong J, Dong S, Yuan Z, Ou G, Zhang X, Xu P, Lou J, Yang N, Chen P, Xu R, and Li G. Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell cycle-dependent deposition at centromeres. Dev. Cell. 2015.32(1), 68-81.
2. Yan S, Xu Z, Lou F, Zhang L, Ke F, Bai J, Liu Z, Liu J, Wang H, Zhu H, Sun Y, Cai W, Gao Y, Su B, Li Q, Yang X, Yu J, Lai Y, Yu X, Zheng Y, Shen N, Chin Y, Wang H. NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis. Nat Commun. 2015, 6:7652.
3. Gao W, Tang Z, Zhang Y, Feng M, Qian M, Dimiter S. Dimitrov and Mitchell Ho*. Immunotoxin targeting glypican-3 regresses liver cancer via dual inhibition of Wnt signalling and protein synthesis．Nature Communications. 2015, 6(3):1-12.
4. Hart JR, Zhang Y, Liao L, Ueno L, Du L, Jonkers M, Yates JR 3rd, Vogt PK. The butterfly effect in cancer: a single base mutation can remodel the cell. Proc Natl Acad Sci U S A. 2015 Jan 27; 112(4):1131-6.
5. Wang H, Ye H, Xie M, Daoud El-Baba M, Fussenegger M. Cosmetics-triggered percutaneous remote control of transgene expression in mice. Nucleic Acids Res. 2015 Aug 18; 43(14):e91.
6. Rodriguez M, Siwko S, Zeng L, Li J, Yi Z, Liu M. Prostate-specific G-protein-coupled receptor collaborates with loss of PTEN to promote prostate cancer progression. Oncogene. 2015 Jun 1. doi: 10.1038/onc.2015.170.
7. Wang Y, Li L, Shao N, Hu Z, Chen H, Xu L, Wang C, Cheng Y*, Xiao J*. Triazine-modified Dendrimer for Efficient TRAIL Gene Therapy in Osteosarcoma, Acta Biomaterialia, 2015, 17, 115-124.
8. Huang L, Lv Q, Liu F, Shi T*, Wen C. A Systems Biology-Based Investigation into the Pharmacological Mechanisms of Sheng-ma-bie-jia-tang Acting on Systemic Lupus Erythematosus by Multi-Level Data Integration. Sci. Rep. 5:16401, (2015).
9. Amjad Ali, Zhang P, Yao L, Sun W, Wang H, Lin X, Dai Y, Feng X, Robb Moses, Wang D, Li X, Xiao J. KLF17 empowers TGF-β/Smad signaling by targeting Smad3-dependent pathway to suppress tumor growth and metastasis during cancer progression. Cell Death & Disease. 2015 Mar 12; 6.
10. Xu J, Huang C, Yang Z, Jin M, Fu P, Zhang N, Luo J, Li D, Liu M, Zhou Y, Zhu Y. Crystal structure of LGR4-Rspo1 complex: insights into the divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors (LGRs). J Biol Chem. 2015 Jan 23; 290(4):2455-65.
11. Deng S, Wu L, Wang Y, Cao P, Xu L, Li Q, Liu M, Zhang L, Jiang Y, Yang X, Sun S, Tan M, Qian M, Zang Y*, Feng L*, Li J*. Protein kinase A rescues microtubule affinity-regulating kinase 2-induced microtubule instability and neurite disruption by phosphorylating serine 409. J Biol Chem. 2015, Jan 30,290(5):3149-3160.
12. Yang X, Li L*, Huang Q, Xu W, Cai X, Zhang J, Yan W, Song D, Liu T, Zhou W, Li Z, Yang C, Dang Y, Xiao J. Wnt signaling through Snail1 and Zeb1 regulates bone metastasis in lung cancer. Am J Cancer Res. 2015 Jan 15; 5(2):748-55.
13. Wang H, Wei H, Liu H, Cheng Y*, Xiao J*. Nucleobase-modified Dendrimers as Nonviral Vectors for Efficient and Low Cytotoxic Gene Delivery, Colloids and Surfaces B, 2015, COLSUB7470, in press.
14. Song D, Meng T, Xu W, Hou T, Lin Z, Yin H, Li B, Zhou L, Wang T, Han S, Fan T, Miao W, Liu M, Luo J, Zhou W, Li Z, Xiao J. 5-Fluoruracil blocked giant cell tumor progression by suppressing osteoclastogenesis through NF-kappaB signals and blocking angiogenesis. Bone. 2015 Sep; 78: 46-54.
15. Chen S, Jiao J, Jiang D, Wan Z, Li L, Li K, Xu L, Zhou Z, Xu W, Xiao J. T-box transcription factor Brachyury in lung cancer cells inhibits macrophage infiltration by suppressing CCL2 and CCL4 chemokines. Tumor Biology, 2015 Aug; 36(8):5881-90.
16. Fang P, Xu W, Li D, Zhao X, Dai J, Wang Z, Yan X, Qin M, Zhang Y, Xu C, Wang L, Qiao Z. A novel acrosomal protein, IQCF1, involved in sperm capacitation and the acrosome reaction. Andrology. 2015 Mar; 3(2):332-44.
17. Xu H, Lv F, Zhang Y, Yi Z*, Ke Q*, Wu C*, Liu M, Chang J. Hierarchically micro-patterned nanofibrous scaffolds with nanosized bio-glass surface for accelerating wound healing. Nanaoscale. 2015 Nov 28; 7(44):18446-52.
18. Xu G* and Wong J*. Oxidative DNA demethylation mediated by Tet enzymes. National Science Review. 2015, 2(3):318-328.
19. Bai M, Li Q, Shao Y, Huang Y, Li D*, Ma Y*. Generation of site-specific mutant mice using the CRISPR/Cas9 system. Yi Chuan. 2015 Oct 20; 37(10):1029-3.