 | | 程义云 教授 2008年于中国科学技术大学获得结构生物学博士学位，2009年在Washington University in St.Louis从事博士后研究；2010年受聘于华东师范大学生命科学学院，担任生命医学研究所生物医学工程专业教授、博士生导师，主要从事纳米医药及生物材料的研究。 |
学术团队
研究骨干
程义云 教授
张 强 副教授
博士研究生
王辉 邵乃敏 王非
硕士研究生
赵晨 王铭明 王辛宇 刘红梅 王仡桐 常虹 刘崇懿
研究兴趣
* 树枝形分子等纳米材料的合成及其在生物医学中的应用研究;
* 基于树枝形分子的主-客体系统的设计及其在药物运输中的应用;
* 生物兼容的纳米材料在早期肿瘤诊断及治疗中的应用研究；
* 将多维核磁等技术应用于纳米药物剂型设计及优化的研究。
国际刊物编辑
2010年至今: Current Drug Discovery Technologies (Regional Editor)
国际刊物编委
《纳米技术》, ISRN Pharmaceutics, World Journal of Nano Science and Engineering
国际刊物审稿人
Nature Materials, Journal of the American Chemical Society, Biomaterials, Journal of Physical Chemistry B, Journal of Physical Chemistry Letters, Journal of Controlled Release, Biomacromolecules, Langmuir, Crystal Growth & Design, New Journal of Chemistry, European Journal of Medicinal Chemistry, Current Drug Delivery, International Journal of Pharmaceutics, Acta Biomaterialia, Bioorganic& Medicinal Chemistry Letters, Bioorganic& Medicinal Chemistry, Polymers, Molecules, Mini-reviews in Medicinal Chemistry, Journal of Biomedical Materials Research Part A, Nanomedicine, Artificial Intelligence in Medicine, Pharmacological Research, Biopolymers, Drug Development and Industrial Pharmacy, Interface Focus, Biochemical Sciences, Spectroscopy Letters, Colloids and Surface B, Journal of Biomaterials Science-Polymer Edition, Journal of Biological Physics, Recent Patents on Biomedical Engineering, Journal of Macromolecular Sciences, Vitae, Expert Opinion on Drug Metabolism and Toxicology, Letters in Organic Chemistry, Current Nanosciences, Current Drug Discovery Technologies, Open Journal of Pharmacology, International Journal of Nanomedicine, Journal of Pharmaceutical Investigation, Recent Patents on Nanomedicine, Journal of Composite Materials, Environmental Research, Letters in Drug Design and Discovery, World Journal of Nano Science and Engineering, Water Environmental Research, Frontiers of Chemical Engineering in China, Chemical Papers, Scientific Research and Essays, Materials, Journal of Nano Research, ISRN Pharmaceutics, Nanotechnology (Scientific Research Publisher).
出版书籍/章节
Cheng YY* (Editor-in-Chief). “Dendrimer-based Drug Delivery Systems: from Theory to Practice”, John Wiley & Sons, 2012.
近五年代表论文
近年来以第一/通讯作者在Nature Materials, Chemical Reviews, Chemical Society Reviews, Journal of the American Chemical Society, Biomaterials等一流刊物发表树枝形分子药物运输系统相关的SCI学术论文40多篇, 影响因子总和 (2010年) 超过200, 其中8篇 (次) 论文为发表当年/季度该杂志最热门文章或引用次数最多的论文(most frequently downloaded/hottest articles)或封面文章, 2篇论文被多家杂志, 媒体或网站Highlight, 论文被他人公开引用800多次 (*通讯作者):
1) Yavuz MS†‚ Cheng YY†‚ Chen JY†‚ Cobley CM‚ Zhang Q‚ Rycenga M‚ Xie JW‚ Kim C‚ Schwartz AG‚ Wang LV‚ Xia YN*. Gold Nanocages Covered by Smart Polymers for Controlled Release with Near-infrared Light‚ Nature Materials‚ 2009‚ 8(12): 935-939. (†共同第一作者; 2010年影响因子29.8; 论文自发表以来被 Science Daily‚ The New York Times‚ R & D Magazines‚ Nanomedicine等多家权威媒体‚杂志Highlight).
2) Hu JJ‚ Xu TW‚ Cheng YY*. NMR Insights into Dendrimer-based Host-guest Systems‚ Chemical Reviews‚ 2012‚ cr-2011-00333h‚ in press. (2010年影响因子33.0).
3) Cheng YY*‚ Zhao LB‚ Li YW‚ Xu TW*. Design of Biocompatible Dendrimers for Cancer Diagnosis and Therapy: Current Status and Furture Perspectives‚ Chemical Society Reviews‚ 2011‚ 40‚ 2673-2703. (2010年影响因子26.5).
4) Zhao LB‚ Wu QL‚ Cheng YY*‚ Zhang JH‚ Wu JH‚ Xu TW*. High-throughput Screening of Dendrimer-binding Drugs‚ Journal of the American Chemical Society‚ 2010‚ 132(38)‚ 13182-13184. (2010年影响因子9.0).
5) Hu JJ‚ Su YZ‚ Zhang HF‚ Xu TW‚ Cheng YY*. Design of interior-functionalized fully acetylated dendrimers for anticancer drug delivery‚ Biomaterials‚ 2011‚32(36): 9950-9959. (2010年影响因子7.9).
6) Zhang Q‚ Wang N‚ Xu TW*‚ Cheng YY*. Poly(amidoamine) Dendronized Hollow Fiber Membranes: Synthesis‚ Characterization‚ and Preliminary Applications as Drug Delivery Devices‚ Acta Biomaterialia‚ 2012‚ 8(3)‚ 1316-1322.
7) Fang M‚ Zhang J‚ Wu Q‚ Xu T*‚ Cheng YY*. Host-Guest Chemistry of Dendrimer-Drug Complexes: 7. Formation of Stable Inclusions between Acetylated Dendrimers and Drugs Bearing Multiple Charges‚ Journal of Physical Chemistry B‚ 2012‚ 116(10)‚ 3075-3082.
8) Shao NM‚ Su YZ‚ Hu JJ‚ Zhang JH‚ Zhang HF*‚ Cheng YY*. Comparison of Generation 3 Polyamidoamine Dendrimer and Generation 4 Polypropylenimine Dendrimer on Drug Loading‚ Complex Structure‚ Release Behavior‚ and Cytotoxicity‚ International Journal of Nanomedicine‚ 2011‚ 6‚ 3361-3372.
9) Wang MM‚ Gong XL‚ Hu JJ‚ Yu YH*‚ Chen Q*‚ Cheng YY*‚ Understanding the Binding Interactions between Dendrimer and 18 Common Amino Acids by NMR Techniques‚ Journal of Physical Chemistry B‚ 2011‚ 115(44)‚ 12728-12735. (封面文章).
10) Zhao C‚ Wang YT‚ Su YZ‚ Zhang HF‚ Ding LX‚ Yan XF‚ Zhao D‚ Shao NM‚ Ye XY*‚ Cheng YY*‚ Inclusion Complexes of Isoflavones with Two Commercially Available Dendrimers: Solubility‚ Stability‚ Structures‚ Release Behaviors‚ Cytotoxicity‚ and Anti-oxidant Activities‚ International Journal of Pharmaceutics‚ 2011‚ 421(2)‚ 301-309.
11) Feng XY‚ Cheng YY*‚ Wu QL‚ Zhang JH‚ Xu TW*‚ Stimuli Response of Cystamine-Core Dendrimer Revealed by Diffusion and NOE NMR Studies‚ Journal of Physical Chemistry B‚ 2011‚ 115(14):3777-3783.
12) Yang K‚ Weng L‚ Cheng YY*‚ Zhang HF*‚ Zhang JH‚ Wu QL‚ Xu TW*‚ Host-Guest Chemistry of Dendrimer-Drug Complexes. 6. Fully Acetylated Dendrimers as Biocompatible Drug Vehicles Using Dexamethasone 21-phosphate as Model Drug‚ Journal of Physical Chemistry B‚ 2011‚ 115(10)‚ 2185-2195.
13) Feng XY‚ Cheng YY*‚ Yang K‚ Zhang J‚ Wu Q‚ Xu TW*. Host-Guest Chemistry of Dendrimer-Drug Complexes‚ 5. Insights into the Design of Formulations for Noninvasive Delivery of Heparin Revealed by Isothermal Titration Calorimetry and NMR Studies‚ Journal of Physical Chemistry B‚ 2010‚ 114 (34): 11017-11026.
14) Fang M‚ Cheng YY*‚ Zhang JH‚ Wu QL‚ Hu JJ‚ Zhao LB‚ Xu TW*. New Insights into the Interactions between Dendrimers and Surfactants: 4. Fast Exchange/Slow Exchange Transitions in the Structure of Dendrimer-Surfactant Aggregates‚ Journal of Physical Chemistry B‚ 2010‚ 114(18): 6048-6055.
15) Yang K‚ Cheng YY*‚ Feng XY‚ Zhang JH‚ Wu QL‚ Xu TW*. New Insights into the Interactions between Dendrimers and Mixed Micelles: 5. Formation of Miscellaneous Mixed Micelles Revealed by a Combination of 1H NMR‚ Diffusion‚ and NOE Analysis‚ Journal of Physical Chemistry B‚ 2010‚ 114(21): 7265-7273.
16) Hu JJ‚ Fang M‚ Cheng YY*‚ Zhang JH‚ Wu QL‚ Xu TW*. Host-Guest Chemistry of Dendrimer-Drug Complexes: 4. An In-depth Look into the Binding/Encapsulation of Guanosine Monophosphate by Dendrimers‚ Journal of Physical Chemistry B‚ 2010‚ 114(21): 7148-7157.
17) Hu JJ‚ Cheng YY*‚ Wu QL‚ Zhao LB‚ Xu TW*. Host-Guest Chemistry of Dendrimer-Drug Complexes: 2. Effects of Molecular Properties of Guests and Surface Functionalities of Dendrimers‚ Journal of Physical Chemistry B‚ 2009‚ 113(31): 10650 - 10659.
18) Zhao LB‚ Cheng YY*‚ Hu JJ‚ Wu QL‚ Xu TW*. Host-Guest Chemistry of Dendrimer-Drug Complexes: 3. Competitive Binding of Multi-drugs to a Single Dendrimer‚ Journal of Physical Chemistry B‚ 2009‚ 113(43): 14172-14179.
19) Hu JJ‚ Cheng YY*‚ Ma YR‚ Wu QL‚ Xu TW*. Host-Guest Chemistry and Physico-chemical Properties of Dendrimer-Mycophenolic Acid Complexes‚ Journal of Physical Chemistry B‚ 2009‚ 113(1): 64-74.
20) Cheng YY*‚ Wu QL‚ Li YW‚ Hu JJ‚ Xu TW*. New Insights into the Interactions between Dendrimers and Surfactants: 2. Design of New Drug Formulations Based on Dendrimer-Surfactant Aggregates‚ Journal of Physical Chemistry B‚ 2009‚ 113(24): 8339-8346.
21) Wu QL‚ Cheng YY*‚ Hu JJ‚ Zhao LB‚ Xu TW*. New Insights into the Interactions between Dendrimers and Surfactants: 3. Size- and Hydrophobicity-Dependent Encapsulation of Bile Salts‚ Journal of Physical Chemistry B‚ 2009‚ 113: 12934-12943.
22) Yang WJ‚ Li YW‚ Cheng YY*‚ Wu QL‚ Wen LP‚ Xu TW*. Evaluation of Phenylbutazone and Poly(amidoamine) Dendrimers Interactions by a Combination of Solubility‚ 2D-NOESY NMR‚ and Isothermal Titration Calorimetry Studies‚ Journal of Pharmaceutical Sciences‚ 2009‚ 98(3): 1075-1085.
23) Cheng YY*†‚ Li YW†‚ Wu QL‚ Zhang JH‚ Xu TW*. Generation-Dependent Encapsulation/Electrostatic Attachment of Phenobarbital Molecules by Poly(amidoamine) Dendrimers: Evidence from 2D-NOESY Investigations‚ European Journal of Medicinal Chemistry‚ 2009‚ 44(5): 2219-2213. (†共同第一作者).
24) Yang WJ‚ Cheng YY*‚ Xu TW*‚ Wang XY‚ Wen LP*. Targeting Cancer Cells with Dendrimer-Biotin Conjugates‚ European Journal of Medicinal Chemistry‚ 2009‚ 44(2): 862-868.
25) Cheng YY*‚ Wu QL‚ Li YW‚ and Xu TW*. External Electrostatic Interaction versus Internal Encapsulation between Cationic Dendrimers and Negatively Charged Drugs: Which Contributes More to Solubility Enhancement of the Drugs? Journal of Physical Chemistry B‚ 2008‚ 112: 8884-8890.
26) Cheng YY*‚ Li YW‚ Wu QL‚ Xu TW*. New Insights into the Interactions between Dendrimers and Surfactants by Two Dimensional NOE NMR Spectroscopy‚ Journal of Physical Chemistry B‚ 2008‚ 112(40): 12674-12680.
27) Cheng YY*‚ Xu ZH‚Ma ML‚Xu TW*. Dendrimers as Drug Carriers: Applications in Different Routes of Drug Administration‚ Journal of Pharmaceutical Sciences‚ 2008‚ 97(1): 123-143. (2008年被选为该杂志十大最热门文章之一; 2009年再次被选为该杂志十大被引次数最多的文章).
28) Cheng YY‚ Wang JR‚Rao TL‚He XX‚ Xu TW*. Pharmaceutical Applications of Dendrimers: Promising Nanocarriers for Drug Delivery‚ Frontiers in Bioscience‚ 2008‚ 13: 1447-1471.
29) Cheng YY*‚ Xu TW*. The Effect of Dendrimers on the Pharmacodynamic and Pharmacokinetic behaviors of Non-covalently or Covalently Attached Drugs‚ European Journal of Medicinal Chemistry‚ 2008‚ 43: 2291-2297.
30) Cheng YY*, Li MZ, Xu TW*, Potential of Poly(amidoamine) Dendrimers as Drug Carriers of Camptothecin Based on Encapsulation Studies, European Journal of Medicinal Chemistry, 2008, 43:1791-1795.
