固有免疫及其调控实验室
| 杜冰 （https://faculty.ecnu.edu.cn/s/291/main.jspy） 研究员、博导 电子邮箱：bdu@bio.ecnu.edu.cn 电话：021-24206964 (Phone) 021-54344922 (Fax) 研究方向：
教学：
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1997年9月-2001年7月 安徽大学 生物化学专业 学士
2001年9月-2006年7月 华东师范大学 生物化学与分子生物学专业 博士
2006年7月-至今 华东师范大学 生命科学学院
2007年10月-2009年3月美国德州农工大学健康科学中心 访问学者
主持国家自然科学基金青年基金项目“Gpr48对固有免疫中病原体相关分子模式识别的调控机制”（31000398），
主持华东师范大学科研创新基金青年项目（78210023）
主持上海市科委基础研究重点项目“Gpr48对固有免疫系统中TLRs相关抗感染免疫功能调控机制研究”（09JC1405200）
主持上海市“晨光计划”项目“基于特异性粘附肽的肝癌靶向治疗研究”（2008CG27）
代表论文（*通讯作者）
[1]. Zhang Na, Huang Hongjun, Tan Binghe, Wei Yinglei, Xiong Qingqing, Yan Yan, Hou Lili, Wu Nannan, Siwko Stefan, Andrea Cimarelli, Xu Jianrong , Han Honghui, Qian Min, Liu Mingyao, *Du Bing. 2017. Leucine-rich repeat-containing G protein-coupled receptor 4 facilitates vesicular stomatitis virus infection by binding vesicular stomatitis virus glycoprotein. Journal of Biological Chemistry, 2017 Aug 23. pii: jbc.M117.802090. doi:
[2]. Zhang Chengfei, He Hongwang, Wang Li, Zhang Na, Huang Hongjun, Xiong Qingqing, Yan Yan, Wu Nannan, Ren Hua, Han Honghui, Liu Mingyao, Qian Min, *Du Bing. 2017. Virus-Triggered ATP Release Limits Viral Replication through Facilitating IFN-β Production in a P2X7-Dependent Manner. Journal of Immunology. 2017 August 15;199 (4) 1372-1381; DOI: https://doi.org/10.4049/jimmunol.1700187
[3]. Huang Hongjun, Zhang Na, Xiong Qingqing, Chen Ruoyu, Zhang Chengfei, Wang Ning, Wang Li, Ren Hua, Liu Mingyao, *Qian Min, *Du Bing. 2017.Elimination of GPR146-mediated antiviral function through IRF3/HES1-signaling pathway. Immunology. 2017 Sep;152(1):102-114. doi: 10.1111/imm.12752.
[4]. Qin Juliang, Zhang Xiaoyu, Wang Ziqiang, Li Jinju, Zhang Zhen, Gao Liangcai, Ren Hua, *Qian Min, *Du Bing. 2017. Presenilin 2 deficiency facilitates Aβ-induced neuroinflammation and injury by upregulating P2X7 expression. SCIENCE CHINA Life Sciences. 2017 Feb;60(2):189-201. doi: 10.1007/s11427-016-0347-4.
[5]. Zhang, X., Qin J., Zou J., Lv Z., Tan B., Shi J., Zhao Y., Ren H., Liu M., Qian M., and *Du Bing. 2016. Extracellular ADP facilitates monocyte recruitment in bacterial infection via ERK signaling. Cellular & Molecular Immunology. 2016 Nov 21. doi: 10.1038/cmi.2016.56.
[6]. Ma Xiaobin, Pan Xinhua, Wei Yinglei, Tan Binhe, Yang Linli, Ren Hua, Qian Min, *Du Bing. 2016. Chemotherapy-induced uridine diphosphate release promotes breast cancer metastasis through P2Y6 activation. Oncotarget. 2016 May 17;7(20):29036-50. doi: 10.18632/oncotarget.8664.
[7]. Shi, G., X. He, *Y. Shang, L. Xiang, C. Yang, G. Han, and *Du Bing. 2016. Synthesis of 3′,4′‐Diaryl‐4′H‐spiro[indoline‐3,5′‐[1′,2′,4′]oxadiazol]‐2‐ones via DMAP‐catalyzed Domino Reactions and Their Antibacterial Activity. Chinese Journal of Chemistry 34: 901-909.
[8]. Qin Juliang, Zhang Guangxu, Zhang Xiaoyu, Tan Binghe, Lv Zhangsheng, Liu Mingyao, Ren Hua, Qian Min, *Du Bing. 2016. TLR-Activated Gap Junction Channels Protect Mice against Bacterial Infection through Extracellular UDP Release. Journal of Immunology. 15;196(4):1790-8.
[9]. Zhang Xiaoyu, Qin Juliang, Zhao Yihan, Shi Jueping, Lan Rong, Gan Yunqiu, Ren Hua, Zhu Bing, Qian Min, *Du Bing. 2016. Long-term ketogenic diet contributes to glycemic control but promotes lipid accumulation and hepatic steatosis in type 2 diabetic mice. Nutrition Research. 36(4):349-58.
[10]. Li Jinju, Zhang Guangxu, Cheng Dalong, Ren Hua, Qian Min, *Du Bing. 2015. Molecular characterization of RIG-I, STAT-1 and IFN-beta in the horseshoe bat. Gene. 561(1):115-23.
[11]. Li Ruimei, Tan Binhe, Yan Yan, Ma Xiaobing, Zhang Na, Zhang Zhi, Liu Mingyao, Qian Min and *Du Bing, 2014. Extracellular UDP and P2Y6 function as a danger signal to protect mice from vesicular stomatitis virus infection through an increase in IFN-beta production. Journal of Immunology. 193, 4515-26.
[12]. Ren Hua, Teng Yunfei, Tan Binhe, Zhang Xiaoyu, Jiang Wei, Liu Mingyao, Jiang Wenzheng, *Du Bing and *Qian, Min, 2014. Toll-like receptor-triggered calcium mobilization protects mice against bacterial infection through extracellular ATP release. Infection and Immunity. 82, 5076-85.
[13]. Du Bing & *Liu Mingyao, 2014. Structure of the human P2Y(1)(2) receptor in complex with an antithrombotic drug. Science China. Life sciences. 57, 645-646.
[14]. Du Bing, Luo Weijia, Li Ruimei, Tan Binghe, Han Honghui, Lu Xiaoling, Li Dali, Qian Min, Zhang Dekai, Zhao Yongxiang, * Liu Mingyao，2013. Lgr4/Gpr48 Negatively Regulates TLR2/4-associated Pattern Recognition and Innate Immunity by Targeting CD14 Expression, Journal of Biological Chemistry. 2013, 288(21), pp 15131-15141.
[15]. Zhao Qufei, Qian Yu, Li Ruimei, Tan Binghe, Han Honghui, Liu Mingyao, * Qian Min, *Du Bing，2012. Norcantharidin Facilitates LPS-Mediated Immune Responses by Up-Regulation of AKT/NF-kappaB Signaling in Macrophages, Plos One, 7(9), p e44956.
[16]. Wang Ziqiang, Jiang Wei, Zhang Zhi, Qian Min, * Du Bing，2012. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kappaB pathway in RAW 264.7 cells, Journal of Ethnopharmacol. 144(1), pp 145-150.
[17]. Pan Xinhua, Han Honghui, Wang Lei, Yang Linli, Li Ruimei, Li Zhenxi, Liu Junchen, Zhao Qufei, Qian Min, * Liu Mingyao, *Du Bing，2011. Nitidine Chloride inhibits breast cancer cells migration and invasion by suppressing c-Src/FAK associated signaling pathway,Cancer Letters, 313(2), pp 181-191.
[18]. Zhang Zhi、Wang Ziqiang、Ren Hua、Yue Miaomiao、Huang Kan、Gu Hongjie、Liu Mingyao、*Du Bing、*Qian Min，2011. P2Y(6) Agonist Uridine 5 '-Diphosphate Promotes Host Defense against Bacterial Infection via Monocyte Chemoattractant Protein-1-Mediated Monocytes/Macrophages Recruitment ，Journal of Immunology, 186(9), pp 5376-5387.
[19]. Han H, Du Bing, Pan X, Liu J, Zhao Q, Lian X, et al. CADPE inhibits PMA-stimulated gastric carcinoma cell invasion and matrix metalloproteinase-9 expression by FAK/MEK/ERK-mediated AP-1 activation. Molecular Cancer Research, 2010;8:1477-88.
[20]. Du Bing, Han H, Wang Z, Kuang L, Wang L, Yu L, et al. Targeted drug delivery to hepatocarcinoma in vivo by phage-displayed specific binding peptide. Molecular Cancer Research, 2010;8:135-44.
[21]. Du Bing, M. Qian, Z. Zhou, P. Wang, L. Wang, X. Zhang, M. Wu, P. Zhang, and B. Mei. 2006. In vitro panning of a targeting peptide to hepatocarcinoma from a phage display peptide library. Biochemical and biophysical research communications 342: 956-962.
参译《免疫生物学（第5版）》，科学出版社，2008年5月出版
参编《免疫学原理与技术》，高等教育出版社，2011年5月出版
主编《免疫学实验指导》高等教育出版社，2011年5月出版