报告题目：COUP-TFII inhibitors in treatment of diseases
报告人：Ming-Jer Tsai, 美国贝勒医学院分子与细胞生物学系教授，美国资深科学家，台湾中研院院士
主持人：翁杰敏 教授
报告时间：2018年9月14日 下午15:30-16:30
报告地点：生命科学学院534小会议室
报告人简介：
1971-1973 Postdoctoral Fellow, Dept. of Developmental Therapeutics, M.D. Anderson Cancer Center, Houston, Texas
1973-1974 Instructor, Dept. of Cell Biology, Baylor College of Medicine, Houston, Texas
1974-1979 Assistant Professor, Dept. of Cell Biology, Baylor College of Medicine, Houston, Texas
1979-1987 Associate Professor, Dept. of Cell Biology, Baylor College of Medicine, Houston, Texas
1988-Present, Professor, Dept. of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas
报告摘要：Prof. Ming-Jer Tsai’s research are to decipher the developmental and physiological functions of nuclear orphan receptors, COUP-TFI, COUP-TFII, nuclear receptor coregulators (SRC-2 and SRC-3) and their roles in disease processes as well as to determine the molecular mechanism of nuclear receptors and their coregulators. On the COUP-TFs, they can be subdivided into 6 different areas. 1. To study COUP-TFII’s role in regulating adipogenesis, bone formation, mesenchymal stem cell fate determination and energy metabolism. 2. To study COUP-TFII’s role in angiogenesis, lymphangiogenesis and heart development. 3. To study COUP-TFII’s role in Leydig cell differentiation and physiological function of the uterus. 4. To study COUP-TFI and -TFII’s roles in organogenesis. Specifically, we are studying their roles in the development of kidney, stomach, cerebellum, eye, hypothalamus and amygdala. 5. To study the role of COUP-TFII in diseases, including obesity, diabetes, diabetic nephropathy, cancer progression and metastasis (especially in prostate cancer), leiomyoma formation, endometriosis, hear failure, muscular dystrophy and congenital diaphragmatic hernia (CDH) as well as to determine the feasibility of using COUP-TFII ligands to treat these diseases such as metabolic syndromes and cancers. 6. To study the role of nuclear receptor coregulators, SRC-3 (NCoA3) and SRC-2 (NCoA2) in prostate cancer progression and metastasis. 7. To generate mouse lines to over express genes important for diseases in a tissue and time specific manner.